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IFRAME A: from the same domain as parent - no sandbox sttribute IFRAME C: from the same domain + sandbox="allow-scripts" in the same domain sandbox="allow-scripts" locked some javascript scripts, should allow all. You can not drag, drop from parent, even draggign msDrop.com menu bar is off. IFRAME C2: from the same domain sandbox="allow-same-origin allow-scripts"		IFRAME B: from other domain - no sandbox sttribute Drag & drop want not work in Chrome IFRAME D2: from other domain sandbox="allow-same-origin allow-scripts" IFRAME D: from other domain + sandbox="allow-scripts" Drag and drop events works on iframe when open Chromium or Chrome without build restrictions. For test run Chrome or Chromium with flag - chromium-browser --disable-web-security - or google-chrome --disable-web-security - or chrome.exe --disable-web-security After that, all events dragover, dragenter, dragleave and drop works over iframes